Cytogenetic Department
Cytogenetics Department | Dr. Daneshbod Pathobiology Laboratory, Shiraz
The Cytogenetics Department of Dr. Daneshbod Pathobiology Laboratory in Shiraz is one of the advanced and specialized centers for the diagnosis of chromosomal abnormalities. Utilizing modern laboratory equipment, a standardized working environment, and operating under the supervision of Dr. Sadat Noori (Fellowship in Molecular Pathology and Cytogenetics), this department provides accurate and reliable diagnostic services to patients and the medical community.
The primary focus of this unit is Conventional Cytogenetics, which involves detailed evaluation of the number and structural integrity of chromosomes. Molecular cytogenetics services are performed separately in the Molecular Cytogenetics Department of the laboratory.
What is Cytogenetics?
Cytogenetics is a branch of genetics that studies chromosomes and their relationship to human diseases. Any alteration in the number or structure of chromosomes may lead to congenital disorders, infertility, or malignancies.
At Dr. Daneshbod Laboratory, chromosomal analysis is performed on two primary specimen types:
• Peripheral blood
• Bone marrow aspirate
All procedures are conducted in accordance with strict laboratory standards and quality protocols.
Specialized Cytogenetic Services at Dr. Daneshbod Laboratory
A comprehensive range of karyotype analysis services is offered in this department.
1. Peripheral Blood Karyotype Analysis
This test is used to evaluate genetic abnormalities with hereditary or congenital origins. Major clinical applications include:
• Evaluation of infertility: Detection of chromosomal abnormalities that may impair fertility.
• Recurrent pregnancy loss: Investigation of parental balanced chromosomal translocations that may lead to miscarriage.
• Pubertal and growth disorders: Assessment of delayed puberty, short stature, or disorders of sex development (e.g., Turner syndrome or Klinefelter syndrome).
• Family history assessment: Evaluation of individuals with a family history of intellectual disability or congenital anomalies prior to pregnancy.
2. Bone Marrow Karyotype Analysis
This service is primarily used for the diagnosis and management of hematologic malignancies (Onco cytogenetics).
Clinical applications include:
• Accurate diagnosis of leukemias: Detection of numerical and structural chromosomal abnormalities in diseases such as AML, CML, and ALL.
• Myelodysplastic syndromes (MDS): Assisting in the diagnosis and classification of these complex hematologic disorders.
• Prognostic assessment: Predicting disease course and therapeutic response based on cytogenetic findings.
• Treatment monitoring: Evaluating the effectiveness of chemotherapy or bone marrow transplantation.
Importance of Cytogenetic Diagnosis in Cancer
Cytogenetics is one of the cornerstones in the diagnosis of hematologic malignancies. Identification of specific chromosomal abnormalities—such as the Philadelphia chromosome t(9;22) in Chronic Myeloid Leukemia (CML) or the t(15;17) translocation in Acute Promyelocytic Leukemia (APL)—not only confirms the diagnosis but also directly influences the selection of targeted therapies and treatment protocols.
Why Choose the Cytogenetics Department at Dr. Daneshbod Laboratory?
By combining experience, expertise, and advanced technology, this center provides several distinctive advantages:
1. Expert Scientific Team
The Cytogenetics Department operates under the supervision of Dr. Sadat Noori (Fellowship in Molecular Pathology and Cytogenetics) with scientific and analytical management by Dr. Leila Kohan (PhD in Molecular Biology).
A specialized team with more than a decade of experience in chromosomal analysis, together with senior genetics technologists, ensures accurate analysis and expert interpretation, even in complex cases.
2. Advanced Equipment and Digital Analysis
The use of advanced imaging systems and karyotype analysis software compliant with international standards ensures high-resolution imaging and precise detection of subtle structural abnormalities.
3. Accurate and Reliable Results
All cell culture and slide preparation procedures are performed using optimized protocols, and results undergo review and final validation by senior specialists.
4. Rapid Turnaround Time
Understanding the importance of timely diagnosis—especially in hematology and oncology—the laboratory is committed to providing results as quickly as possible without compromising diagnostic accuracy.
5. Direct Collaboration with Medical Specialists
Comprehensive and analytical reports are provided to hematologists, pathologists, and geneticists, enabling precise clinical decision making and personalized patient management.
6. Comprehensive Quality Control (QC)
Continuous internal and external quality control programs ensure the accuracy, reliability, and reproducibility of all cytogenetic results.
A Trusted Choice for Critical Diagnostic Decisions
The Cytogenetics Department of Dr. Daneshbod Pathobiology Laboratory is recognized as one of the leading cytogenetics centers in Shiraz, providing specialized services in chromosomal analysis of peripheral blood and bone marrow while maintaining the highest standards of scientific precision and professional ethics.